Small Molecule interactions with Membrane Proteins
In-solution characterization of affinity and structural properties of the FcRn IgG1 Fc interaction during product development
Characterising Multivalent Complex Formation Using Controlled Complex Lifetime in Fida 1
Small Molecule Interactions with Membrane Proteins
Antigen footprint governs activation of the B cell receptor
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes Bioconjugate
FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC
Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats
Label-free biophysical assays using nanoliter sample volumes
Technote: The Relationship between hydrodynamic radius and molecular weight
Clone Selection from unpurified samples
Protein Quantification in plasma (probing immune responses in patients)
PDB Correlator Linking Structure and Function
Rapid characterization of LLPS with FIDA
Fully automated characterization of ternary complex formation using flow induced dispersion analysis
High Throughput detergent screening for membrane proteins using nanoliters of sample
Assessment of sample quality with every measurement - Fida 1 Fundamentals
Flow Induced Dispersion Analysis to measure gRNA-Nuclease Interactions for CRISPR-CAS Development
An automated methodology for assesment of protein stability using nanograms of protein
360-degree automated characterization of AAVs: The safe solution for gene therapy
Rapid sizing and characterization of bispecific antibodies
Characterization of Molecular Glues - an automated in-solution platform
Targeted Protein Degradation - Full Characterization of Ternary complexes
Correlating Supramolecular Behaviour in Buffer and Plasma
Screening conformational stability using nanograms of protein
Assessment of Sample Quality with every measurement. FIDA 1 Fundamentals.
Quantification and Characterization of Exosomes
Assessment of protein Stability and Functionality by Flow Induced Dispersion Analysis
Linking Structure and Function: Use PDB data as the baseline for your Fidabio characterisation
Protein Oligomerization: Easy and Accurate determination in plasma and buffer
High throughput detergent screening for membrane proteins
Use of FIDA for rapid characterization of liquid-liquid phase separation
Size-based characterization of peptide-liposome interactions
Easy and Rapid Assessment of Protein ubiquitination, e.g. in PROTAC development
Selective quantification of IgG Directly in F12 Fermentation Media
Functional Characterization of Nanodisc embedded GPCR
Fidabio Clone Selection Assay: Protein Expression Level and affinity directly in fermentation media without purification (Clone Selection from Non-Purified Samples)
Characterization of Conformational Changes by flow induced dispersion analysis
Detection of Auto-Antibodies in Systemic Lupus Erythematosus Patients
Characterizing Multivalent Complex Formation (Agglutination of multivalent antibodies)
360-degree automated characterization of AAVs, safe solution for gene therapy
Rapid Sizing And Characterization of Bispecific Antibodies using nL of Sample
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Case-based applications
& Publications
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A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry
Publications
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry
Author Information
Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation
Publications
Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation
Author Information
Bi-directional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners
Publications
Bi-directional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners
Author Information
The Protein-Templated Synthesis of Enzyme-Generated Aptamers
Publications
The Protein-Templated Synthesis of Enzyme-Generated Aptamers
Author Information
Quantification of Structural Integrity and Stability Using Nanograms of Protein by Flow-Induced Dispersion Analysis
Publications
Quantification of Structural Integrity and Stability Using Nanograms of Protein by Flow-Induced Dispersion Analysis
Author Information
Assessment of immunogenicity and drug activity in patient sera by flow-induced dispersion analysis
Publications
Assessment of immunogenicity and drug activity in patient sera by flow-induced dispersion analysis
Author Information
A lipid transfer protein ensures nematode cuticular impermeability.
Publications
A lipid transfer protein ensures nematode cuticular impermeability.
Author Information
Antigen footprint governs activation of the B cell receptor
Publications
Antigen footprint governs activation of the B cell receptor
Author Information
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes Bioconjugate
Publications
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes Bioconjugate
Author Information
FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC
Publications
FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC
Author Information
Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats
Publications
Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats
Author Information
Literature
Rapid, Precise Information for Fast and Safe Drug Development
Based on our revolutionary, patented FIDA technology, Fidabio offers rapid, precise information on complex binding interactions and concentration of proteins, particles up to 1,000 nm Dh, antibodies, and other biomolecules.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
The core measurements of the FIDA technology, or Flow-Induced-Dispersion- Analysis, are very precise and reproducible, absolute detections of hydrodynamic radii directly in plasma, serum, fermentation media, cell lysate etc. with accuracies of +/- 5 %, coefficient of variations of <5 % and a sensitivity of 0.1 nM FITC type tags. The instrument is fully automated for vials or 2 x 96 wells plates with end-to-end temperature control from 4-55 °C controllable in increments of 0.1 °C. Each test only requires a few hundred nanoliters of sample material.
The FIDA technology provides significant advantages over current technologies in terms of data quality, cost, versatility and time. In other words, Fidabio enables scientists and researchers to carry out tests that are impossible using current technologies leading to faster and safer drug development.
Fida 1 Overview
Fida 1 Fundamentals: Assessment of Sample Quality with every measurement
Poster: Assessment of sample quality with every measurement – Fida 1 Fundamentals
Technote: The Relationship between hydrodynamic radius and molecular weight
Analysis of Large Particles
The FIDA technology allows the analysis of proteins and particles 0.5 to 1,000 nm in diameter. This enables analysis of exosomes, liposomes, vaccines, viral vectors, membrane-embedded proteins, intrinsically disordered proteins et. al.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
With the Fidabio instrument you can amongst others analyse interactions between targets and membrane proteins and vaccines, characterization of exosomes, liposome and IDPs, quantification of specific exosomes in plasma, quantification of viral vectors in fermentation media etc.
Analysis Directly in Complex Matrices
It is well-known that detection in a buffer, sample preparations and immobilization from time to time impact the data reliability. Detection directly under native conditions ensures you that your decisions are based on the most biologically accurate data.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
The FIDA technology is based on in-solution measurements. You can analyze directly in plasma, serum, cell lysate, fermentation media, CHO cells et al. Background noise is eliminated by an automatic adjustment of the baseline and the risk of adsorption is managed with our advanced, proprietary capillary coating.
In-solution Validation Immobilization Data
SPR and BLI are industry standards and are widely used for amongst others affinity Kd determination. Though often robust and reliable, occasionally the surface immobilization might result in difficult-to-interpret artefacts due to mass transport limitations.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
With easy setup and validation of new assays and the consumption of only a few hundred nanoliters of sample material, the Fidabio instrument offers a possibility of fast and accurate orthogonal validation of Kd data generated with SPR, BLI etc.
At Fidabio we support young talents. We help PhDs and Postdocs to make their research visible worldwide.
If you would like to travel to present your research findings file an application for Fidabio Young Scientist Travel Grant.
If you would like to travel to present your research findings file an application for Fidabio Young Scientist Travel Grant.